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dc.creatorGarcía Guerrero, Estefaníaes
dc.creatorSánchez Abarca, Luis Ignacioes
dc.creatorDomingo, Estheres
dc.creatorRamos, Teresa L.es
dc.creatorBejarano García, José Antonioes
dc.creatorGonzález Campos, Josées
dc.creatorCaballero Velázquez, Teresaes
dc.creatorPérez Simón, José Antonioes
dc.date.accessioned2022-02-14T12:26:34Z
dc.date.available2022-02-14T12:26:34Z
dc.date.issued2018
dc.identifier.citationGarcía Guerrero, E., Sánchez Abarca, L.I., Domingo, E., Ramos, T.L., Bejarano García, J.A., González Campos, J.,...,Pérez Simón, J.A. (2018). Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.01971.
dc.identifier.issn1664-3224es
dc.identifier.urihttps://hdl.handle.net/11441/129942
dc.description.abstractThe relevance of the immune system in cancer has long been studied. Autologous adoptive T cell therapies, based on the use of tumor infiltrating lymphocytes (TILs), have made great progress in recent years for the treatment of solid tumors, especially melanoma. However, further work is needed to isolate tumor-reactive T cells among patients diagnosed with hematologic malignancies. The dynamics of the interaction between T cells and antigen presenting cells (APC) dictate the quality of the immune responses. While stable joints between target cells and T lymphocytes lead to the induction of T cell activation and immune response, brief contacts contribute to the induction of immune-tolerance. Taking advantage of the strong interaction between target cell and activated T-cells, we show the feasibility to identify and isolate tumor-specific cytotoxic T lymphocytes (CTLs) from acute myeloid leukemia (AML) patients by flow cytometry. Using this technology, CTLs bound through T cell receptor (TCR) to tumor cells can be identified in peripheral blood and bone marrow and subsequently selected and isolated by FACS-based cell sorting. These CTLs display higher percentage of effector cells and marked cytotoxic activity against AML blasts. In conclusion, we have developed a new procedure to identify and select specific cytotoxic T cells in patients diagnosed with acute myeloid leukemia.es
dc.description.sponsorshipInstituto de Salud Carlos III PFIS-FI12/00189es
dc.description.sponsorshipInstituto de Salud Carlos III ISCIII PI14/02074es
dc.description.sponsorshipInstituto de Salud Carlos III PI11/02366es
dc.description.sponsorshipInstituto de Salud Carlos III PI17/02177es
dc.description.sponsorshipEuropean Union (ERDF/ESF, Investing in your future)es
dc.description.sponsorshipCIBER CB16/12/00480es
dc.formatapplication/pdfes
dc.format.extent15es
dc.language.isoenges
dc.publisherFrontiers Media, S.A.es
dc.relation.ispartofFrontiers in Immunology, 9.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectImmunotherapyes
dc.subjectTumor-specific T cellses
dc.subjectAcute myeloid leukemiaes
dc.subjectCell selectiones
dc.subjectT cell-tumor cell synapsees
dc.titleSelection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.identifier.doi10.3389/fimmu.2018.01971es
dc.journaltitleFrontiers in Immunologyes
dc.publication.volumen9es

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