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dc.contributor.advisor
dc.creatorPérez Simón, José Antonio
dc.creatorAfram, Gabriel
dc.creatorMartino, Rodrigo
dc.creatorPiñana, José L.
dc.creatorCaballero Velázquez, Teresa
dc.creatorRingden, Olle
dc.creatorValcárcel, D.
dc.creatorCaballero, Dolores
dc.creatorRemberger, Mats
dc.creatorDe Paz, Yanira
dc.creatorSierra, Jordi
dc.creatorSan Miguel, Jesús
dc.creatorHagglund, Hans
dc.date.accessioned2022-02-09T07:42:13Z
dc.date.available2022-02-09T07:42:13Z
dc.date.issued2011
dc.identifier.citationPérez Simón, J.A., Afram, G., Martino, R., Piñana, J.L., Caballero Velázquez, T., Ringden, O.,...,Hagglund, H. (2011). Evaluation of prognostic factors among patients with chronic graft-versus-host disease. Haematologica, 97 (8), 1187-1195.
dc.identifier.issn0390-6078es
dc.identifier.issn1592-8721es
dc.identifier.urihttps://hdl.handle.net/11441/129792
dc.description.abstractBackground: Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation with an adverse effect on both mortality and morbidity. In 2005, the National Institute of Health proposed new criteria for diagnosis and classification of chronic graft-versus-host disease for clinical trials. New sub-categories were recognized such as late onset acute graft-versus-host disease and overlap syndrome. Design and methods: We evaluated the prognostic impact of the new sub-categories as well as the clinical scoring system proposed by the National Institute of Health in a retrospective, multicenter study of 820 patients undergoing allogeneic stem cell transplantation between 2000 and 2006 at 3 different institutions. Patients were retrospectively categorized according to the National Institute of Health criteria from patients' medical histories. Results: As far as the new sub-categories are concerned, in univariate analysis diagnosis of overlap syndrome adversely affected the outcome. Also, the number of organs involved for a cut-off value of 4 significantly influenced both cGVHD related mortality and survival. In multivariate analysis, in addition to NIH score, platelet count and performance score at the time of cGVHD diagnosis, plus gut involvement, significantly influenced outcome. These 3 variables allowed us to develop a simple score system which identifies 4 subgroups of patients with 84%, 64%, 43% and 0% overall survival at five years after cGVHD diagnosis (score 0: HR=15.96 (95% CI: 6.85-37.17), P<0.001; score 1: HR=5.47 (95% CI: 2.6-11.5), P<0.001; score 2: HR=2.8 (95% CI: 1.32-5.93), P=0.007). Conclusions: In summary, we have identified a powerful and simple tool to discriminate different subgroups of patients in terms of chronic graft-versus-host disease related mortality and survival.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.language.isoenges
dc.publisherFerrata-Storti Foundationes
dc.relation.ispartofHaematologica, 97 (8), 1187-1195.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcGVHDes
dc.subjectPrognostic factorses
dc.subjectNIH classificationes
dc.subjectOverlap syndromees
dc.subjectDelayed acute GVHDes
dc.titleEvaluation of prognostic factors among patients with chronic graft-versus-host diseasees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.identifier.doi10.3324/haematol.2011.055244es
dc.journaltitleHaematologicaes
dc.publication.volumen97es
dc.publication.issue8es
dc.publication.initialPage1187es
dc.publication.endPage1195es

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