Article
Synthesis and Characterization of New Biocompatible Amino Amphiphilic Compounds Derived from Oleic Acid as Nanovectors for Drug Delivery
Author/s | Valdivia Giménez, Victoria Esther
Paggiaro, Chiara Fernández Fernández, Inmaculada |
Department | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Publication Date | 2019 |
Deposit Date | 2021-12-22 |
Published in |
|
Abstract | Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble ... Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types of macromolecular structures such as micelles, monolayer vesicles, bars, sheets and tubes. In this work, a convergent synthetic approach for the synthesis of two new amphiphilic compounds based on a versatile amino polar head, a tetraethylene glycol spacer and a lipophilic tail derived from oleic acid has been developed. Subsequently, after a self-assembly process in aqueous medium, nanostructures as micelles have been obtained and characterized. Finally, a procedure for the inclusion of the highly lipophilic drug Dexamethasone has been carried out in order to study the ability of these micelles to act as nanovectors for drug delivery. |
Funding agencies | Ministerio de Economía y Competitividad (MINECO). España |
Project ID. | CTQ2016-78580-C2-2-R |
Citation | Valdivia Giménez, V.E., Paggiaro, C. y Fernández Fernández, I. (2019). Synthesis and Characterization of New Biocompatible Amino Amphiphilic Compounds Derived from Oleic Acid as Nanovectors for Drug Delivery. Proceedings, 41 (1), 1. |
Files | Size | Format | View | Description |
---|---|---|---|---|
proceedings-41-00001.pdf | 1.102Mb | [PDF] | View/ | |