dc.creator | Bruzelius, Andreas | es |
dc.creator | Hidalgo, Isabel | es |
dc.creator | Boza Serrano, Antonio | es |
dc.creator | Hjelmér, Anna Giorgia | es |
dc.creator | Tison, Amelie | es |
dc.creator | Deierborg, Tomas | es |
dc.creator | Bengzon, Johan | es |
dc.creator | Ramos Moreno, Tania | es |
dc.date.accessioned | 2021-09-22T15:06:27Z | |
dc.date.available | 2021-09-22T15:06:27Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Bruzelius, A., Hidalgo, I., Boza Serrano, A., Hjelmér, A.G., Tison, A., Deierborg, T.,...,Ramos Moreno, T. (2021). The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches. Stem cells translational medicine, 10 (4), 582-597. | |
dc.identifier.issn | 2157-6564 | es |
dc.identifier.issn | 2157-6580 | es |
dc.identifier.uri | https://hdl.handle.net/11441/126113 | |
dc.description.abstract | Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors that populate the developing CNS. Interestingly, a specific type of bone marrow-derived monocyte is able to express a yolk sac microglial signature and populate CNS in disease. Here we have examined human bone marrow (hBM) in an attempt to identify novel cell sources for generating microglia-like cells to use in cell-based therapies and in vitro modeling. We demonstrate that hBM stroma harbors a progenitor cell that we name stromal microglial progenitor (STR-MP). STR-MP single-cell gene analysis revealed the expression of the consensus genetic microglial signature and microglial-specific genes present in development and CNS pathologies. STR-MPs can be expanded and generate microglia-like cells in vitro, which we name stromal microglia (STR-M). STR-M cells show phagocytic ability, classically activate, and survive and phagocyte in human brain tissue. Thus, our results reveal that hBM harbors a source of microglia-like precursors that can be used in patient-centered fast derivative approaches. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Stem cells translational medicine, 10 (4), 582-597. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Bone marrow | es |
dc.subject | Common myeloid progenitor | es |
dc.subject | Human bone marrow | es |
dc.subject | Microglia | es |
dc.subject | Microglia-like cell in vitro model | es |
dc.subject | Microglial precursor | es |
dc.subject | Pluripotent stem cell | es |
dc.subject | Primitive myeloid progenitor | es |
dc.title | The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | https://doi.org/10.1002/sctm.20-0127 | es |
dc.identifier.doi | 10.1002/sctm.20-0127 | es |
dc.journaltitle | Stem cells translational medicine | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 582 | es |
dc.publication.endPage | 597 | es |