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dc.creatorDiez-Hermano, Sergioes
dc.creatorGanfornina, María Doloreses
dc.creatorSkerra, Arnees
dc.creatorGutiérrez Pozo, Gabrieles
dc.creatorSánchez Romero, Diegoes
dc.date.accessioned2021-09-08T12:01:29Z
dc.date.available2021-09-08T12:01:29Z
dc.date.issued2021
dc.identifier.citationDiez-Hermano, S., Ganfornina, M.D., Skerra, A., Gutiérrez Pozo, G. y Sánchez Romero, D. (2021). An Evolutionary Perspective of the Lipocalin Protein Family. Frontiers in Physiology, 12, 718983.
dc.identifier.issn1664-042Xes
dc.identifier.urihttps://hdl.handle.net/11441/125574
dc.description.abstractThe protein family of Lipocalins is ubiquitously present throughout the tree of life, with the exception of the phylum Archaea. Phylogenetic relationships of chordate Lipocalins have been proposed in the past based on protein sequence similarities, but their highly divergent primary structures and a shortage of experimental annotations in genome projects have precluded a well-supported hypothesis for their evolution. In this work we propose a novel topology for the phylogenetic tree of chordate Lipocalins, inferred from multiple amino acid sequence alignments. Sixteen jawed vertebrates with fair coverage by genomic sequencing were compared. The selected species span an evolutionary range of ∼400 million years, allowing for a balanced representation of all major vertebrate clades. A consensus phylogenetic tree is proposed following a comparison of sequence-based maximum-likelihood trees and protein structure dendrograms. This new phylogeny suggests an APOD-like common ancestor in early chordates, which gave rise, via whole-genome or tandem duplications, to the six Lipocalins currently present in fish (APOD, RBP4, PTGDS, AMBP, C8G, and APOM). Further gene duplications of APOM and PTGDS resulted in the altogether 15 Lipocalins found in contemporary mammals. Insights into the functional impact of relevant amino acid residues in early diverging Lipocalins are also discussed. These results should foster the experimental exploration of novel functions alongside the identification of new members of the Lipocalin family.es
dc.description.sponsorshipEspaña Ministerio de Ciencia e Innovación grant PID2019-110911RB-I00es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Physiology, 12, 718983.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLipocalines
dc.subjectCalycines
dc.subjectprotein phylogenyes
dc.subjectfunctional divergencees
dc.subjectmolecular evolutiones
dc.titleAn Evolutionary Perspective of the Lipocalin Protein Familyes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDgrant PID2019-110911RB-I00es
dc.relation.publisherversionhttp://dx.doi.org/10.3389/fphys.2021.718983es
dc.identifier.doi10.3389/fphys.2021.718983es
dc.journaltitleFrontiers in Physiologyes
dc.publication.volumen12es
dc.publication.endPage718983es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes

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