A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

Gómez González, Belén; Sessa, Gaetana; Carreira, Aura; Aguilera López, Andrés

doi:10.1080/23723556.2021.1910474

Artículo

dc.creator	Gómez González, Belén	es
dc.creator	Sessa, Gaetana	es
dc.creator	Carreira, Aura	es
dc.creator	Aguilera López, Andrés	es
dc.date.accessioned	2021-09-02T13:50:29Z
dc.date.available	2021-09-02T13:50:29Z
dc.date.issued	2021
dc.identifier.citation	Gómez González, B., Sessa, G., Carreira, A. y Aguilera López, A. (2021). A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin. Molecular and Cellular Oncology, 8 (3), 1910474.
dc.identifier.issn	2372-3556	es
dc.identifier.uri	https://hdl.handle.net/11441/125296
dc.description.abstract	In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.	es
dc.format	application/pdf	es
dc.format.extent	6 p.	es
dc.language.iso	eng	es
dc.publisher	Taylor & Francis	es
dc.relation.ispartof	Molecular and Cellular Oncology, 8 (3), 1910474.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	BRCA2	es
dc.subject	Breast cancer	es
dc.subject	DDX5	es
dc.subject	DNA-RNA hybrid	es
dc.subject	Double-strand break	es
dc.subject	DSB repair	es
dc.subject	Homologous recombination	es
dc.title	A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/submittedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Genética	es
dc.relation.publisherversion	https://doi.org/10.1080/23723556.2021.1910474	es
dc.identifier.doi	10.1080/23723556.2021.1910474	es
dc.journaltitle	Molecular and Cellular Oncology	es
dc.publication.volumen	8	es
dc.publication.issue	3	es
dc.publication.initialPage	1910474	es

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