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dc.creatorDopazo, Joaquínes
dc.creatorMaya Miles, Douglases
dc.creatorGarcía, Federicoes
dc.creatorLorusso, Nicolaes
dc.creatorCalleja, Miguel Ángeles
dc.creatorPareja, María Jesúses
dc.creatorLópez Miranda, Josées
dc.creatorRodríguez-Baño, Jesúses
dc.creatorPadillo Ruiz, Francisco Javieres
dc.creatorRomero Gómez, Manueles
dc.date.accessioned2021-07-06T08:01:27Z
dc.date.available2021-07-06T08:01:27Z
dc.date.issued2021-05-26
dc.identifier.citationDopazo, J., Maya-Miles, D., García, F., Lorusso, N., Calleja, M.Á., Pareja, M.J.,...,Romero Gómez, M. (2021). Implementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare system. Journal of personalized medicine, 11 (6)
dc.identifier.issn2075-4426(electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/115195
dc.description.abstractThe COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems.es
dc.description.sponsorshipConsejería de Salud y Familias, Junta de Andalucía, PE-0451-2018; Premed Covid y COVID-GWAses
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofJournal of personalized medicine, 11 (6)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPersonalized medicinees
dc.subjectPrecision medicinees
dc.subjectCovid-19es
dc.subjectSARS CoV2es
dc.subjectEpidemiologyes
dc.subjectHost geneticses
dc.subjectViral genomees
dc.titleImplementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare systemes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Cirugíaes
dc.relation.projectIDPE-0451-2018es
dc.relation.publisherversionhttps://www.mdpi.com/journal/jpmes
dc.identifier.doi10.3390/jpm11060475es
dc.journaltitleJournal of personalized medicinees
dc.publication.volumen11es
dc.publication.issue6es

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