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dc.creatorFernández, Raquel Maríaes
dc.creatorPeciña, Anaes
dc.creatorLozano Arana, María Doloreses
dc.creatorSánchez, Beatrizes
dc.creatorGarcía-Lozano, Juan Carloses
dc.creatorBorrego, Saludes
dc.creatorAntiñolo Gil, Guillermoes
dc.date.accessioned2021-06-21T16:38:03Z
dc.date.available2021-06-21T16:38:03Z
dc.date.issued2015-11-18
dc.identifier.citationFernández, R.M., Peciña, A., Lozano Arana, M.D., Sánchez, B., García-Lozano, J.C., Borrego, S. y Antiñolo Gil, G. (2015). Clinical and Technical Overview of Preimplantation Genetic Diagnosis for Fragile X Syndrome: Experience at the University Hospital Virgen del Rocio in Spain. Biomed Research International, 2015, art.n.965839.
dc.identifier.issn2314-6141 (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/114706
dc.description.abstractFragile X syndrome (FXS) accounts for about one-half of cases of X-linked intellectual disability and is the most common monogenic cause of mental impairment. Reproductive options for the FXS carriers include preimplantation genetic diagnosis (PGD). However, this strategy is considered by some centers as wasteful owing to the high prevalence of premature ovarian failure in FXS carriers and the difficulties in genetic diagnosis of the embryos. Here we present the results of our PGD Program applied to FXS, at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Roc´ıo in Seville. A total of 11 couples have participated in our PGD Program for FXS since 2010. Overall, 15 cycles were performed, providing a total of 43 embryos. The overall percentage of transfers per cycle was 46.67% and the live birth rate per cycle was 13.33%. As expected, these percentages are considerably lower than the ones obtained in PGD for other pathologies. Our program resulted in the birth of 3 unaffected babies of FXS for 2 of the 11 couples (18.2%) supporting that, despite the important drawbacks of PGD for FXS, efforts should be devoted in offering this reproductive option to the affected families.es
dc.description.sponsorshipFundación Pública Andaluza Progreso y Salud (Consejería de Salud) Junta de Andalucía (PI-0105-2011)es
dc.formatapplication/pdfes
dc.format.extent7 p.es
dc.language.isoenges
dc.publisherHindawies
dc.relation.ispartofBiomed Research International, 2015, art.n.965839.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFragile X syndromees
dc.subjectFXSes
dc.subjectPGD Programes
dc.titleClinical and Technical Overview of Preimplantation Genetic Diagnosis for Fragile X Syndrome: Experience at the University Hospital Virgen del Rocio in Spaines
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Cirugíaes
dc.relation.projectIDPI-0105-2011es
dc.relation.publisherversionhttps://www.hindawi.com/journals/bmri/2015/965839/es
dc.identifier.doi10.1155/2015/965839es
dc.journaltitleBiomed Research Internationales
dc.publication.volumen2015es
dc.publication.initialPageart.n.965839es

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