Browsing Artículos (Ingeniería Mecánica y de Fabricación) by Subject "Postmenopausal osteoporosis"
Now showing items 1-5 of 5
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An in silico approach to elucidate the pathways leading to primary osteoporosis: age‑related vs. postmenopausal
(Springer, 2024)Numerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal ...
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Article
Are drug holidays a safe option in treatment of osteoporosis? — Insights from an in silico mechanistic PK–PD model of denosumab treatment of postmenopausal osteoporosis
(Elsevier, 2021-01)Recent reviews by the clinical bone research community suggest caution with prescription of drug holidays for patients ...
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Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover
(Frontiers Media S.A., 2022-06)Denosumab (Dmab) treatment against postmenopausal osteoporosis (PMO) has proven very efficient in increasing bone mineral ...
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Effects of long-term treatment of denosumab on bone mineral density: insights from an in-silico model of bone mineralization
(Elsevier, 2019)Denosumab is one of the most commonly prescribed anti-resorptive drugs for the treatment of postmenopausal osteoporosis. ...
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Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response
(Frontiers Media S.A., 2022-08-17)Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting ...