Artículos (Instituto de Biomedicina de Sevilla (IBIS)): Envíos recientes
Mostrando ítems 221-240 de 303
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals, 2017)The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction ...
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Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate
(Impact Journals, 2016)The hypoxia-inducible factor 1a (HIF-1a) and its microRNA target, miR-210, are candidate tumor-drivers of metabolic ...
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HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
(Impact Journals, 2017)Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT ...
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Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival
(Impact Journals, 2016-01-04)Current larynx preservation treatments have achieved an improvement of laryngoesophageal dysfunction-free survival (LDS) ...
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Targeted Simplification Versus Antipseudomonal Broad-Spectrum Beta-Lactams in Patients With Bloodstream Infections Due to Enterobacteriaceae (SIMPLIFY): A Study Protocol for a Multicentre, Open-Label, Phase III Randomised, Controlled, Non-Inferiority Clinical Trial.
(2017-06-09)Introduction Within the context of antimicrobial stewardship programmes, de-escalation of antimicrobial therapy is one ...
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The rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary disease.
(2019-02-25)Introduction: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of ...
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GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease.
(Public Library Of Science, 2016-12-28)The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson’s ...
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Distribution and Outcomes of a Phenotype- Based Approach to Guide COPD Management: Results from the CHAIN Cohort
(Public Library Of Science., 2016-11-02)Rationale The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: ...
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Identification of different mechanisms leading to PAX6 down-regulation as potential events contributing to the onset of Hirschsprung disease
(2016-02-16)Hirschsprung disease (HSCR) is attributed to a failure of neural crest derived cells to migrate, proliferate, differentiate ...
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Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.
(2016-10-14)Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival ...
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Design, implementation and evaluation of a web-based computer-tailored intervention to prevent binge drinking in adolescents: study protocol
(2018-04-04)Background: Binge-drinking in adolescents is a highly prevalent healthcare problem that associates physical and mental ...
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Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies
(2016-08-12)Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) ...
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Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.
(Wiley Online, 2016-04-13)In models of Parkinson’s disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axonstabilizing effects on ...
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Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study.
(2018-12-18)Introduction Patients with negative blood cultures (BCx) represent 85%–90% of all patients with BCx taken during hospital ...
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Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients
(2019-08-06)Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient ...
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Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
(2016)It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to ...
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Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation.
(Nature Research, 2016-06-23)Sox2 is a pluripotency transcription factor that as an oncogene can also regulate cell proliferation. Therefore, genes ...
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Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src.
(Impact Journals, 2016-04-20)Despite the development of new antineoplastic agents for the treatment of colorectal cancer (CRC), oxaliplatin and ...
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The prognosis of patients hospitalized with a first episode of heart failure, validation of two scores: PREDICE and AHEAD
(2019-02-21)Purpose: Heart failure (HF) is a chronic, frequent and disabling condition but with a modifiable course and a large ...
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Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial
(2019-11-28)Background: Colistin is recommended in the empirical treatment of ventilator-associated pneumonia (VAP) with a high ...