Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER): Envíos recientes
Mostrando ítems 81-100 de 188
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Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
(Frontiers Media S.A., 2019-05-16)Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental ...
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Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells
(Springer Nature, 2019-09)Aims/hypothesis: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical that has been associated with type 2 ...
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The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes
(Springer Nature, 2019-07-18)Mutations in NIPBL are the major cause of Cornelia de Lange Syndrome (CdLS). NIPBL is the cohesin-loading factor and has ...
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation
(Elsevier, 2017)The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic ...
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Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling
(Frontiers Media, 2019)Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also ...
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BRCA1 Accelerates CtIP-Mediated DNA-End Resection
(Elsevier, 2014)DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In ...
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Rat1p maintains RNA polymerase II CTD phosphorylation balance
(Cold Spring Harbor Laboratory Press, 2014)In S. cerevisiae, the 5′-3′ exonuclease Rat1p partakes in transcription termination. Although Rat1p-mediated RNA degradation ...
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Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
(Public Library of Science, 2015)Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular ...
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Manganese Redistribution by Calcium-stimulated Vesicle Trafficking Bypasses the Need for P-type ATPase Function
(American Society for Biochemistry and Molecular Biology, 2015)Regulation of intracellular ion homeostasis is essential for eukaryotic cell physiology. An example is provided by loss ...
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Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
(Frontiers Media, 2017)In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease ...
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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder
(Elsevier, 2016)From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) ...
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs
(Elsevier, 2016)Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells ...