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Now showing items 111-120 of 189
Article
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
(eLife Sciences Publications, 2022)
The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed and modulate intracellular signaling events ...
Article
Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
(eLife Sciences Publications, 2016)
Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the ...
Article
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and ...
Article
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, ...
Article
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R ...
Article
Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)
Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed ...
Article
Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles
(2011)
Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of protein molecules. Most commercial paramagnetic particles are synthesized by laborious and costly ...
Article
Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks
(Elsevier (Cell Press): OAJ, 2019)
Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential ...
Article
SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)
Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be ...
Article
A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice
(Ferrata Storti Foundation, 2017)
GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are critically involved in hematopoiesis. An enhancer (G2) of the mouse Gata4 gene directs its expression ...