Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por agencia financiadora "Ministerio de Ciencia, Innovación y Universidades (MICINN). España"
Mostrando ítems 1-6 de 6
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Artículo
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
(American Chemical Society, 2023)We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...
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Glutamine, MTOR and autophagy: a multiconnection relationship
(Taylor & Francis, 2022)Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...
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Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine ...
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Manganese is a physiologically relevant TORC1 activator in yeast and mammals
(eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...
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Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks
(Elsevier (Cell Press): OAJ, 2019)Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms ...