Artículo
Glutamine, MTOR and autophagy: a multiconnection relationship
Autor/es | Bodineau, Clément
Tomé, Mercedes Murdoch, Piedad del Socorro Durán, Raúl V. |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-10-31 |
Publicado en |
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Resumen | Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation. Our recent investigation ... Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation. Our recent investigation identified that the connection between glutamine and AMPK is not restricted to glutaminolysis. Rather, we demonstrated the crucial role of ASNS (asparagine synthetase (glutamine-hydrolyzing)) and the GABA shunt for the metabolic control of the AMPK-MTORC1 axis during glutamine sufficiency. Our results elucidated a metabolic network by which glutamine metabolism regulates the MTORC1-macroautophagy/autophagy pathway through two independent branches involving glutaminolysis and ASNS-GABA shunt. |
Agencias financiadoras | Agencia Estatal de Investigación. España Ministerio de Ciencia, Innovación y Universidades (MICINN). España Consejo Superior de Investigaciones Científicas (CSIC) |
Identificador del proyecto | PGC2018-096244- B-I00
SAF2016-75442-R |
Cita | Bodineau, C., Tomé, M., Murdoch, P.d.S. y Durán, R.V. (2022). Glutamine, MTOR and autophagy: a multiconnection relationship. Autophagy, 18 (11), 2749–2750. https://doi.org/10.1080/15548627.2022.2062875. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Glutamine MTOR.pdf | 603.5Kb | [PDF] | Ver/ | |