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Artículo
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Benzothiazole Derivatives Endowed with Antiproliferative Activity in Paraganglioma and Pancreatic Cancer Cells: Structure–Activity Relationship Studies and Target Prediction Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The antiproliferative effects played by benzothiazoles in different cancers have aroused the interest for these molecules as promising antitumor agents. In this work, a library of phenylacetamide derivatives containing the ...
Artículo
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Sucrose esters from Physalis peruviana calyces with anti-inflammatory activity
(Georg Thieme Verlag, 2014)
Physalis peruviana is a native plant from the South American Andes and is widely used in tra- ditional Colombian medicine of as an anti-inflam- matory medicinal plant, specifically the leaves, calyces, and small stems in ...
Artículo
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Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
(MDPI, 2022)
The preparation of new and functional nanostructures has received more attention in the scientific community in the past decade due to their wide application versatility. Among these nanostructures, micelles appear to be ...
Artículo
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Magnetic Nanoparticles as MRI Contrast Agents
(Springer, 2020)
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high ...
Artículo
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Evaluación de la actividad anti-adenovirus de diferentes librerías químicas de pequeñas moléculas y caracterización de su mecanismo de acción
(Universidad Pablo de Olavide, 2015)
Motivación: El adenovirus humano (HAdV) es un virus que causa infecciones autolimitadas y leves en individuos inmunocompetentes, en cambio, en pacientes inmunodeprimidos las infecciones ...
Artículo
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Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
(Royal Society of Chemistry, 2017)
Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. ...
Artículo
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Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices
(Wiley-Blackwell, 2021)
As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown ...
Tesis Doctoral
Tesis Doctoral
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Nuevas aplicaciones de N-sulfiniliminas: síntesis de aziridinas y aminoalcoholes ópticamente puros
(1999-06-28)
Nos propusimos como objetivos de esta memoria los siguientes:1) Síntesis estereoselectivas de N- sulfiniliminas con distintos sustituyentes en el azufre sulfinílico, con ... La síntesis de N- sulfiniliminas α,β-insaturadas, ...