Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
|Author||Valdivia Giménez, Victoria
Gimeno Ferrero, Raúl
Pernia Leal, Manuel
Fernández Romero, Ana María
González Rodríguez, María Luisa
Fernández Fernández, Inmaculada
|Department||Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
|Abstract||The preparation of new and functional nanostructures has received more attention in the scientific community in the past decade due to their wide application versatility. Among these nanostructures, micelles appear to be ...
The preparation of new and functional nanostructures has received more attention in the scientific community in the past decade due to their wide application versatility. Among these nanostructures, micelles appear to be one of the most interesting supramolecular organizations for biomedical applications because of their ease of synthesis and reproducibility and their biocompatibility since they present an organization similar to the cell membrane. In this work, we developed micellar nanocarrier systems from surfactant molecules derived from oleic acid and tetraethylene glycol that were able to encapsulate and in vitro release the drug dexamethasone. In addition, the designed micelle precursors were able to functionalize metallic NPs, such as gold NPs and iron oxide NPs, resulting in monodispersed hybrid nanomaterials with high stability in aqueous media. Therefore, a new triazole-derived micelle precursor was developed as a versatile encapsulation system, opening the way for the preparation of new micellar nanocarrier platforms for drug delivery, magnetic resonance imaging, or computed tomography contrast agents for therapeutic and diagnostic applications.
|Funding agencies||Ministerio de Ciencia e Innovación (MICIN). España
Ministerio de Ciencia, Innovación y Universidades (MICINN). España
Junta de Andalucía. Consejería de Transformación Económica, Industria, Conocimiento y Universidad. España
P18-RT-1663 PAIDI 2020 and P20-01171
|Citation||Valdivia Giménez, V., Gimeno Ferrero, R., Pernia Leal, M., Paggiaro, C., Fernández Romero, A.M., González Rodríguez, M.L. y Fernández Fernández, I. (2022). Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles. Nanomaterials, 12 (10), 1753.|