NamePernia Leal, Manuel
DepartmentQuímica Orgánica y Farmaceútica
Knowledge areaQuímica Orgánica
Professional categoryProfesor Titular de Universidad
E-mailRequest
           
  • No. publications

    21

  • No. visits

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  • No. downloads

    2691


 

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Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment

Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; Lerena, Patricia; Pozo, Esther; Serrano, Rosario; Calero, Raúl; Pintado, Cristina; Pernia Leal, Manuel; Moreno Rodríguez, Nazaret; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2024)
Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ...
PhD Thesis
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Derivados de d-Galactosa como antagonistas de los receptores NK1 de interés terapéutico: aproximaciones al diseño de nuevos nanosistemas teranósticos

Pozo Torres, Esther; Fernández Fernández, Inmaculada; Pernia Leal, Manuel (2023)
A pesar de los enormes esfuerzos tanto económicos como científicos invertidos en la lucha contra el cáncer, éste sigue ...
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Deciphering the Parameters to Produce Highly Reproducible and Scalable Iron Oxide Nanoparticles

Avasthi, Ashish; Caro Salazar, Carlos; García-Martín, María Luisa; Pernia Leal, Manuel (Royal Society of Chemistry, 2023)
Nanomedicine has been long hailed as a game changer for treating several ailments, but its translation from bench to bedside ...
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Scaling Up Magnetic Nanobead Synthesis with Improved Stability for Biomedical Applications

Bigall, Nadja C.; Rodio, Marina; Avugadda, Sahitya; Pernia Leal, Manuel; Di Corato, Riccardo; Conteh, John S.; Intartaglia, Romuald; Pellegrino, Teresa (American Chemical Society, 2022)
The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications ...
Article
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Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles

Valdivia Giménez, Victoria Esther; Gimeno Ferrero, Raúl; Pernia Leal, Manuel; Paggiaro, Chiara; Fernández Romero, Ana María; González Rodríguez, María Luisa; Fernández Fernández, Inmaculada (MDPI, 2022)
The preparation of new and functional nanostructures has received more attention in the scientific community in the past ...
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Passive targeting of high-grade gliomas via the EPR effect: a closed path for metallic nanoparticles?

Caro Salazar, Carlos; Avasthi, Ashish; Páez-Muñoz, José María; Pernia Leal, Manuel; García-Martín, María Luisa (Royal Society of Chemistry, 2021)
Passive tumor targeting via the enhanced permeability and retention (EPR) effect has long been considered the most effective ...
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Fe₃ O₄-Au Core-Shell Nanoparticles as a Multimodal Platform for in Vivo Imaging and Focused Photothermal Therapy

Caro Salazar, Carlos; Gámez Márquez, Francisco; Quaresma, Pedro; Páez-Muñoz, José María; Domínguez Moreno, Alejandro; Pearson, John R.; Pernia Leal, Manuel; Beltrán, Ana M.; Fernandez-Afonso, Yilian; Fuente, Jesús M. de la; Franco, Ricardo; Pereira, Eulália; García-Martín, María Luisa (MDPI, 2021)
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au ...
Final Degree Project
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Nanomedicinas para el diagnóstico y tratamiento del glioblastoma

Garrido Díaz, Natalia; Pernia Leal, Manuel (2021)
El glioblastoma es considerado el tumor primario cerebral más frecuente y agresivo en adultos, siendo 15 meses la ...
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PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents

Caro Salazar, Carlos; Páez-Muñoz, José María; Beltrán, Ana M.; Pernia Leal, Manuel; García-Martín, María Luisa (American Chemical Society, 2021)
Diagnostic imaging strongly relies on the use of contrast agents (CAs). In general terms, current CAs present undesirable ...
Article
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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization

Pozo Torres, Esther; Caro Salazar, Carlos; Páez-Muñoz, José María; García-Martín, María Luisa; Fernández Fernández, Inmaculada; Pernia Leal, Manuel (Taylor and Francis Group, 2020)
Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications ...
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Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

Nica, Valentín; Caro Salazar, Carlos; Páez-Muñoz, José María; Pernia Leal, Manuel; García-Martín, María Luisa (MDPI, 2020)
In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and ...
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Magnetic Nanoparticles as MRI Contrast Agents

Avasthi, Ashish; Caro Salazar, Carlos; Pozo Torres, Esther; Pernia Leal, Manuel; García-Martín, María Luisa (Springer, 2020)
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic ...
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Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications

Caro Salazar, Carlos; Egea Benavente, David; Polvillo, Rocio; Royo, José Luis; Pernia Leal, Manuel; García-Martín, María Luisa (Elsevier, 2019)
Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic ...
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Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification

Caro Salazar, Carlos; Quaresma, Pedro; Pereira, Eulalia; Franco, Jaime; Pernia Leal, Manuel; García-Martín, María Luisa; Oliva Montero, José María (MDPI, 2019)
Progress in the field of biocompatible SERS nanoparticles has promising prospects for biomedical applications. In this ...
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Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Materia, Maria Elena; Pernia Leal, Manuel; Scotto, Marco; Balakrishnan, Preethi Bala; Kumar Avugadda, Sahitya; Garcı́a Martı́n, Marı́a Luisa; Cohen, Bruce E.; Chan, Emory M.; Pellegrino, Teresa (American Chemical Society, 2017)
We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and ...
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Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents

Caro Salazar, Carlos; Dalmases, Mariona; Figuerola, Albert; García-Martín, María Luisa; Pernia Leal, Manuel (Royal Society of Chemistry, 2017)
X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous ...
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Synthesis of 1D-glyconanomaterials by a hybrid noncovalent–covalent functionalization of single wall carbon nanotubes: a study of their selective interactions with lectins and with live cells

Pernia Leal, Manuel; Assali, Mohyeddin; Cid Martín, J.J.; Valdivia Giménez, Victoria Esther; Franco, J. M.; Fernández Fernández, Inmaculada; Pozo, D.; Khiar, Noureddine (Royal Society of Chemistry, 2015)
To take full advantage of the remarkable applications of carbon nanotubes in different fields, there is a need to develop ...
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Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail

Assali, Mohyeddin; Pernia Leal, Manuel; Fernández Fernández, Inmaculada; Romero Gómez, Pablo; Baati, Rachid; Khiar, Noureddine (Springer, 2010)
We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ...
Patent
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Neoglicolipidos, sus agregados con nanotubos de carbono, procedimiento de obtencion y aplicaciones

Khiar El Wahabi, Noureddine; Pernia Leal, Manuel; Fernández Fernández, Inmaculada (Oficina Española de Patentes y Marcas , 2009)
La presente invención se refiere a un glicolípido de fórmula (I) en la que R es un carbohidrato seleccionado entre un ...
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Tailoring carbon nanotube surfaces with glyconanorings: New bionanomaterials with specific lectin affinity

Khiar, Noureddine; Pernia Leal, Manuel; Baati, Rachid; Ruhlmann, Christine; Mioskowski, Charles; Schultz, Patrick; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2009)
Remarkably stable, water-soluble glyconanoring-coated SWCNTs were prepared by self organization and photopolymerization ...