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Artículo
Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems
(American Society for Biochemistry and Molecular Biology, Inc., 2017-04-03)
Pathogenic Acinetobacter species, including Acinetobacter baumannii and Acinetobacter nosocomialis, are opportunistic human pathogens of increasing relevance worldwide. Although their mechanisms of drug resistance are ...
Artículo
Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS
(Lippincott, Williams & Wilkins, 2017)
Objective: Several factors influence the clinical course of autoimmune inflammatory diseases such as MS and inflammatory bowel disease. Only recently, the complex interaction between the gut microbiome, dietary factors, ...
Artículo
Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF‑mutated melanoma treated in the randomized coBRIM study
(Biomed Central LTD, 2017)
Background: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAFV600-mutated ...
Artículo
miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemiareperfusion injury
(Nature Research, 2017)
Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) injuries. However, little is known about their role in posttranscriptional regulation in the process of ...
Artículo
Prevalence of drug interactions in elderly patients with multimorbidity in primary care
(Springer Nature, 2017)
Background Drug interactions (DIs) are a significant cause of medicationrelated problems. The aging population, high chronic diseases prevalence and polypharmacy are closely associated factors. Aim of the review To study ...
Artículo
Bacteraemia due to non-ESBL-producing Escherichia coli O25b:H4 sequence type 131: insights into risk factors, clinical features and outcomes
(Elsevier, 2017)
The epidemiology and outcomes of bloodstream infections (BSIs) caused by Escherichia coli ST131 isolates not producing extended-spectrum β-lactamases (ESBLs) are not well defined despite being more prevalent than ESBL-producers. ...
Artículo
Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study)
(Hindawi, 2017)
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi ...
Artículo
Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease
(Public Library of Science, 2017)
The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a frontrostriatal dopamine-mediated syndrome, which leads to executive deficits, and a posterior cortical ...
Artículo
Variability in adherence to clinical practice guidelines and recommendations in COPD outpatients: a multi-level, cross-sectional analysis of the EPOCONSUL study
(BioMed Central, 2017)
Background: Clinical audits have reported considerable variability in COPD medical care and frequent inconsistencies with recommendations. The objectives of this study were to identify factors associated with a better adherence ...