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Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
Artículo
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
(Sociedad Española de Patología Digestiva, 2018-02-01)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or ...