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Mostrando ítems 1-10 de 18
Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
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Artículo
Stratification of patients in NASH clinical trials: a pitfall for trial success
(Elsevier, 2020)
Identifying the most effective therapeutic intervention in patients with NAFLD is challenging. Precise stratification in clinical trials is key to ensuring the inclusion of patients who will benefit (and not those who will ...
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New therapeutic perspectives in non-alcoholic steatohepatitis
(Elsevier, 2018-02-23)
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean ...
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
(2012)
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ...
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Síndrome LPAC secundario a deleción del exón 4 del gen ABCB4 en un paciente con hepatitis C
(Arán Ediciones, S. L., 2014)
El síndrome LPAC (low-phospholipid-associated cholelithiasis syndrome) está asociado a mutaciones del gen ABCB4, que codifica la proteína MDR3, esencial en la secreción de fosfatidilcolina en las sales biliares. Este ...
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Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
(Sociedad Española de Patología Digestiva, 2018-02-01)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or ...
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Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice
(Medycyna Praktyczna, 2020)
Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that encompasses various forms of liver damage not caused by chronic alcohol consumption. In the absence of other etiologies, it ranges from steatosis to ...
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Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis
(Thieme Medical Publishers, 2016-06)
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized by acute decompensation in patients with chronic liver disease and extrahepatic organ failure. ...
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Analysis of the burden and variability in the management of NAFLD patients in the clinical practice: unifying the required criteria
(Sociedad Española de Patología Digestiva, 2019)
Aim: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in the gastroenterology outpatient clinic and describe the use of the resources accordingly. Methods: a prospective and observational study of 403 ...