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Knowledge of disease and access to a specialist reported by Spanish patients with ulcerative colitis. UC-LIFE survey
(Aran Ediciones S.A., 2017)
colitis (UC) about their disease and access to a specialist are important to improve health outcomes. Our objective was to determine, by collecting information directly from the patients, their information sources ...
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Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
(Aran Ediciones S.A., 2017)
Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation ...
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Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression
(Frontiers Media S.A., 2023)
Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological ...
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Ustekinumab in Crohn’s disease: real-world outcomes and predictors of response
(Aran Ediciones S.A., 2022)
Background: ustekinumab is a monoclonal antibody that inhibits interleukins IL-12 and IL-23, and is approved for the treatment of Crohn’s disease (CD) and, more recently, also ulcerative colitis (UC). The aim of this ...
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ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
(Frontiers Media S.A., 2023-12-11)
Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD (SR-aGVHD). Based on recent Phase-III study results, ruxolitinib has become the new standard of ...
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Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia
(Elsevier, 2023-01-10)
Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect survival. However, it remains uninvestigated during routine diagnostic workups. We hypothesized ...
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Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021-10-21)
Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In heavily pretreated patients, who have already received proteasome inhibitors, immunomodulatory drugs ...
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Diagnostic accuracy of circulating microRNA in hepatitis B virus-related hepatocellular carcinoma: a meta-analysis based on Asian data
(Aran Ediciones S.A., 2022)
Background and aim: hepatitis B virus (HBV) is the main risk factor for hepatocellular carcinoma (HCC). We performed a meta-analysis based on Asian data to evaluate the diag nostic accuracy of circulating microRNA as ...
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Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori
(Aran Ediciones S.A., 2022)
Introduction: the primary goal of this study was to com pare gastrointestinal symptom reduction in patients on bismuth-containing quadruple eradication therapy sup plemented with Lactobacillus reuteri strains (DSM 17938 ...
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Efficacy and safety of tofacitinib in the treatment of ulcerative colitis: real-life experience in Andalusia
(Aran Ediciones S.A., 2022)
Background: tofacitinib is a Janus kinase inhibitor approved for the treatment of moderate-severe ulcerative colitis (UC). This study aimed to evaluate its efficacy in a real-life setting. Methods: a retrospective and ...