Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Artículo
Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
Autor/es | Ontanilla-Clavijo, Guillermo
Praena Segovia, Julia Giráldez Gallego, Álvaro Cordero Matia, María Elisa Sousa Martín, José Manuel |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2017 |
Fecha de depósito | 2024-05-21 |
Publicado en |
|
Resumen | Epstein-Barr virus, a member of the Herpesviridae family, is
responsible for the infectious mononucleosis clinical syndrome,
which mainly includes the pharyngitis, fever, and lymphadenopathy
triad after incubation ... Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation. |
Cita | Ontanilla-Clavijo, G., Praena Segovia, J., Giráldez Gallego, Á., Cordero Matia, M.E. y Sousa Martín, J.M. (2017). Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus. Revista Española de Enfermedades Digestivas, 109 (5), 388-390. https://doi.org/10.17235/reed.2017.4072/2015. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Severe acute hepatitis.pdf | 575.5Kb | [PDF] | Ver/ | |