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Novel genes and sex differences in COVID-19 severity
(OXFORD UNIV PRESS, 2022)
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE ...
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A meta-analysis of medications directed against PCSK9 in familial hypercholesterolemia
(Elsevier Ireland, 2021)
Background and aims Several medications targeting PCSK9 reduce LDL-cholesterol (LDL-C) in heterozygous familial hypercholesterolemia (HeFH). We aimed to assess in patients diagnosed clinically as HeFH, whether LDL-C ...
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Growth rate controls mRNA turnover in steady and non-steady states
(Taylor & Francis, 2016)
Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases ...
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Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
(American Society for Microbiology, 2013-04)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems are among the recommended empirical treatments for health care-associated complicated intra-abdominal ...
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Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity
(Wiley-Blackwell, 2022)
Background and Purpose: Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible isomerase responsible for prostaglandin E2 production in inflammatory con ditions. We evaluated the role of mPGES-1 in the development ...
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Potential tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli
(2021-05-26)
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as monotherapies or in combination with clinically relevant ...
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La pandemia por SARS-COV-2 y la tercera revolución sanitaria de Sir Muir Gray
(Ministerio de Sanidad , Consumo y Bienestar Social, 2020-11-11)
Pequeño ensayo descriptivo y filosófico en donde se analizan los cambios profesionales que hemos sufrido los médicos de familia tras la primera ola de la pandemia poe SARS-COV-2.
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Extracellular Vesicles as Biomarkers in Liver Disease
(MDPI, 2022-12-19)
Extracellular vesicles (EVs) are membrane-derived vesicles released by a variety of cell types, including hepatocytes, hepatic stellate cells, and immune cells in normal and pathological conditions. Depending on their ...
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Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk
(SPRINGER, 2022)
Purpose To assess the association between three diferent a priori dietary patterns adherence (17-item energy reduced Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as ...