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Mostrando ítems 1-10 de 11
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
Artículo
Elixir of life thwarting aging with regenerative reprogramming
(Lippincott williams & wilkins, 2018-01)
All living beings undergo systemic physiological decline after ontogeny, characterized as aging. Modern medicine has increased the life expectancy, yet this has created an aged society that has more predisposition to ...
Artículo
Generation of human organs in pigs via interspecies blastocyst complementation
(Wiley-Blackwell Verlag GmbH, 2016-10-19)
More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical use is still met with several challenges, such as ethical concerns regarding the need of human embryos, ...
Artículo
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and ...
Artículo
Interspecies chimerism with mammalian pluripotent stem cells
(CELL PRESS, 2017)
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated ...
Artículo
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
(Nature Publishing Group, 2016)
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children1,2,3, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type ...
Artículo
Neurotransmitter Modulation of Carotid Body Germinal Niche
(MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which ...
Artículo
An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
(CELL PRESS, 2014-01-16)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells ...
Artículo
In vivo amelioration of age-associated hallmarks by partial reprogramming
(CELL PRESS, 2016-12-15)
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has ...
Artículo
Carotid body oxygen sensing and adaptation to hipoxia
(Springer, 2015-09)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our understanding of CB function and its role in disease mechanisms has progressed considerably in the ...