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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable 02 tension (Po2). In normoxic conditions ...
Artículo
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Preclinical [18F]tetrafluoroborate-PET/CT imaging of pituitary gland hyperplasia
(Oxford, 2018)
By blocking of sodium–iodide symporter (NIS) in thyroid gland with potassium perchlorate administered in drinking water to rats for 18 months, we provoke hyperplasia of thyroid which led to thyroid cancer, but also of ...
Artículo
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Oxygen sensing by ion channels and chemotransduction in single glomus cells
(1996)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a polarized carbon fiber electrode. Exposure to low PO2 produced a rise of cytosolic [Ca2+] with two ...
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The role of non-coding RNAs in autophagy during carcinogenesis
(Frontiers Media S.A., 2022)
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality control processes to maintain cellular homeostasis. The alteration of autophagy has been implicated ...
Artículo
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Practical Application of Networks in Neurosurgery: Combined 3-Dimensional Printing, Neuronavigation, and Preoperative Surgical Planning
(Elsevier, 2020)
BACKGROUND: A plethora of cutting-edge neuroimaging analyses have been developed and published, yet they have not hitherto been realized as improvements in neurosurgical outcomes. In this paper we propose a novel interface ...
Artículo
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Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
(SOC NEUROSCIENCE, 2011-02-09)
Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane called active zones (AZs). The relationships between AZs, quantal release, and vesicle replenishment ...
Artículo
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Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II
(Frontiers Research Foundation, 2022)
The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit information with exquisite spatio-temporal precision, and (2) to prevent the spread of unspecific ...
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Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cáncer
(Elsevier, 2020)
Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered malignancies. Sorafenib is the first ...
Artículo
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Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells inAMslices of neonatal and adult ...
Artículo
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Peripheral Organ Equivalent Dose Estimation Procedure in Proton Therapy
(Frontiers Research Foundation, 2022)
The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in ...