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Mostrando ítems 241-250 de 332
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Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice
(MDPI, 2021)
α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated with early-onset PD, therefore the ...
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A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma
(American Chemical Society, 2021)
Despite the recent advances in cancer therapeutics, highly aggressive cancer forms, such as glioblastoma (GBM), still have very low survival rates. The intracellular scaffold protein syntenin, comprising two postsynaptic ...
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Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons
(1991)
Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration of the patch-clamp technique. All cells exhibited a large Na+ current with characteristic fast ...
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Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
(Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, measurements of O 2 permeability of lipid bilayers have indicated that it is much lower than previously ...
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Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium
(2000)
We have developed a thin-slice preparation of whole rat carotid body that allows us to perform patch-clamp recording of membrane ionic currents and to monitor catecholamine secretion by amperometry in single glomus cells ...
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Mechanisms of Granule Membrane Recapture followingExocytosis in Intact Mast Cells
(American Society for Biochemistry and Molecular Biology, 2013-05-24)
In secretory cells, several exocytosis-coupled forms of endocytosis have been proposed including clathrin-mediated endocytosis, kiss-and-run endocytosis, cavicapture, and bulk endocytosis. These forms of endocytosis can ...
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Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion
(1986)
The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast cells. Membrane potential of these cells has been measured with intracellular microelectrodes. Our ...
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Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening
(SPRINGER, 2022)
Background Gliomas are typically considered to cause relatively few neurological impairments. However, cognitive difcul ties can arise, for example during treatment, with potential detrimental efects on quality of life. ...
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Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
(American Association for the Advancement of Science, 2022)
Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, proliferation, and cytokine production. Epigenetic control of the genome also governs T cell transcriptome ...