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Effect of Vitamin D on Graft-versus-Host Disease
(MDPI, 2022)
The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical ...
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Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction
(2006)
Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce contraction without the need of extracellular Ca2_ influx. This metabotropic action of Ca2_ channels ...
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Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound
(Public Library of Science, 2012-05-18)
Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many physiological functions. Aquaporin-based modulator drugs are predicted to be of broad potential utility ...
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
(Nature Portfolio, 2020)
Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin ...
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Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma
(Impact Journals, 2017)
Pediatric tumors arise upon oncogenic transformation of stem/progenitor cells during embryonic development. Given this scenario, the existence of non-tumorigenic stem cells included within the aberrant tumoral niche, ...
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Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus
(PLOS, 2021)
Brain aquaporin 1 (AQP1) and AQP4 are involved in cerebrospinal fluid (CSF) homeostasis and might participate in the origin of hydrocephalus. Studies have shown alterations of perivascular AQP4 expression in idiopathic ...
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The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals
(Wiley, 2009-03)
We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin (spH), confirming and extending earlier work at room temperature, which had revealed fluorescent ...
Artículo
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Agregación de alfa-sinucleína y degeneración Parkinsoniana
(Sociedad Española de Ciencias Fisiológicas, 2013)
La alfa-sinucleína es la proteína principal de los cuerpos de Lewy, marcador anatomopatológico de la enfermedad de Parkinson. Dicha proteína puede ver alterada su conformación y adquirir capacidad autoagregante, lo que ...
Artículo
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Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...