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Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
(Wiley, 2018)
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded α-synuclein (αSyn) protein, is known to contribute to the pathophysiology of Parkinson’s disease (PD). In ...
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Brain micro-architecture and disinhibition a latent phenotyping study across 33 impulsive and compulsive behaviours
(Nature Publishing Group, 2020-09-12)
Impulsive and compulsive symptoms are common, tend to co-occur, and collectively account for a substantive global disease burden. Latent phenotyping offers a promising approach to elucidate common neural mechanisms conferring ...
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Carotid body oxygen sensing and adaptation to hipoxia
(Springer, 2015-09)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our understanding of CB function and its role in disease mechanisms has progressed considerably in the ...
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Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions
(AMER PHYSIOLOGICAL SOC, 2015)
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. J Neurophysiol 114: 2404 –2417, 2015. First published July 22, 2015; doi:10.1152/jn.00577.2015.—STX1 ...
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Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
(Wolters Kluwer Health, 2017)
Objective-Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage ...
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SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals
(2011-10-12)
Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease in infants characterized by muscle weakness and impaired synaptic transmission. We report here ...
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Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body
(Cell Press, 2017)
Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
(Wiley, 2017-09)
Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla (AM),and is necessary for adaptation to hypoxia. ...