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MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages
(MDPI, 2022)
Macrophages constitute a major part of the tumor-infiltrating immune cells. Within the tumor microenvironment, they acquire an alternatively activated, tumor-supporting phenotype. Factors released by tumor cells are crucial ...
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SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells
(MDPI, 2021)
Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be grouped into different categories, including the luminal (estrogen receptor positive (ER+)) and triple ...
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MCTP system model based on linear programming optimization of apertures obtained from sequencing patient image data maps
(Wiley, 2014)
Purpose: We present a hybrid direct MLC aperture optimization model exclusively based on sequencing of patient imaging data to be implemented on a Monte Carlo 30 treatment planning system (MC-TPS) to allow the explicit ...
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Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research
(Elsevier, 2020)
In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational ...
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SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models
(MDPI, 2022-10-20)
muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and nuclear gems and that catalyzes spliceosomal snRNP particle synthesis. In cultured motor neurons, SMN is also present in dendrites ...
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Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy
(Public Library of Science, 2019-01-09)
In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning ...
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Multiple Holdouts With Stability: Improving the Generalizability of Machine Learning Analyses of Brain–Behavior Relationships
(Elsevier, 2020)
BACKGROUND: In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiological constructs that combine ...
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TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure
(MDPI AC, 2018-09-14)
Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, ...
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Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes
(Elsevier, 2020)
Background: Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits, but the underlying changes in brain structure that mechanistically link genomic variation to schizotypal experience ...