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Mostrando ítems 111-120 de 332
Artículo
Editorial: Out-of-field second primary cancer induction Dosimetry and modelling
(Frontiers Media, 2022-12-05)
Second primary cancer induction is a growing concern, particularly for the younger cancer patient population with a longer life expectancy, as demonstrated by the increasing number of publications on the topic. Still, there ...
Artículo
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
(NATL ACAD SCIENCES, 2019-07-18)
Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF ...
Artículo
Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
(Frontiers Media S.A., 2022)
The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. ...
Artículo
Statistical Agnostic Mapping: A framework in neuroimaging based on concentration inequalities
(Elsevier, 2021-02)
In the 1970s a novel branch of statistics emerged focusing its effort on the selection of a function for the pattern recognition problem that would fulfill a relationship between the quality of the approximation and ...
Artículo
Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome clinical and genetic study in a series of Spanish patients
(BMC, 2022-02-28)
Background The limited knowledge about the PTEN hamartoma tumor syndrome (PHTS) makes its diagnosis a challenging task. We aimed to define the clinical and genetic characteristics of this syndrome in the Spanish population ...
Artículo
Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
(Elsevier, 2020-03-16)
Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular stress, and sustained angiogenesis, invasiveness and metastatic potential. Cancer cells adequately ...
Artículo
Role of the holoenzyme PP1-SPN in the dephosphorylation of the rb family of tumor suppressors during cell cycle
(MDPI, 2021-05-06)
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance ...
Artículo
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels ...
Artículo
3D VMAT Verification Based on Monte Carlo Log File Simulation with Experimental Feedback from Film Dosimetry.
(Public Library Of Science., 2016-11-21)
A model based on a specific phantom, called QuAArC, has been designed for the evaluation of planning and verification systems of complex radiotherapy treatments, such as volumetric modulated arc therapy (VMAT). This model ...
Artículo
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease
(2011)
In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas. Neurons degenerating in HD develop ...