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Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
(Frontiers Research Foundation, 2021)
Essential tremor (ET) is a highly prevalent neurological disorder characterized by action- induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, ...
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Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations
(BMC, 2022)
Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the peripheral synapse composed of a motor nerve terminal, a muscle specialization, and non-myelinating ...
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Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
(Nature Publishing Group, 2016)
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children1,2,3, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type ...
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Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by 02 tension
(1991)
Type I cells of the carotid body are known to participate in the detection of 02 tension in arterial blood but the primary chemotransduction mechanisms are not well understood. Here we report the existence in excised ...
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Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The tyrosine kinase inhibitor Sorafenib (Sfb) remains the globally accepted treatment for advanced HCC. ...
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body
(1989)
Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole cell variant of the patch-clamp technique. Type II cells only have a tiny, slowly activating outward ...
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Native α-synuclein, 3-nitrotyrosine proteins, and patterns of nitro-α-synuclein-immunoreactive inclusions in saliva and submandibulary gland in parkinson’s disease
(MDPI, 2021-05-01)
Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-αsynuclein (3-NT-αSyn), hold promise as biomarkers for idiopathic Parkinson’s disease (IPD). Nitrative stress that is characterized by an ...
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Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept
(Nature Publishing Group, 2022)
The human brain is a highly plastic ‘complex’ network—it is highly resilient to damage and capable of self-reorganisation after a large perturbation. Clinically, neurological deficits secondary to iatrogenic injury have ...
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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells
(Springer Nature, 2020)
Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and Cabozantinib have shown non-inferior antitumoral activities compared ...
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Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
(Elsevier, 2015)
Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a ...