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Mostrando ítems 31-40 de 110
Artículo
Neurotransmitter Modulation of Carotid Body Germinal Niche
(MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which ...
Artículo
Age-mediated transcriptomic changes in adult mouse substantia nigra
(2013)
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using ...
Artículo
Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
(National Academy of Sciences, 2022)
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O2-sensing organ is the carotid body (CB), which ...
Artículo
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency
(Federation amer soc exp biol, 2021)
Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound enzyme complex that is involved in both the tricarboxylic acid cycle and the electron transport ...
Tesis Doctoral
Patente. Invención
Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia
(Oficina Española de Patentes y Marcas (OEPM), 1999-07-01)
Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia. Se propone como nueva la utilización en preparados farmacológicos de agentes reductores, y en general aquellos que produzcan ...
Artículo
A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating
(1999)
Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable of forming heterotetramers with other pore-forming subunits to modify their function. We have investigated ...
Capítulo de Libro
La fisiología celular, los canales iónicos y la creación de una biofísica española
(Manuel Cortijo Mérida, 2011)
Artículo
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
(Springer, 2021)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD ...
Artículo
Potassium Channel Types in Arterial Chemoreceptor Cells and Their Selective Modulation by Oxygen
(1992)
Single K+ channel currents were recorded in excised membrane patches from dispersed chemoreceptor cells of the rabbit carotid body under conditions that abolish current flow through Na+ and Ca2+ channels. We have found ...