Now showing items 11-15 of 15
Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions [Article]
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions ...
Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin [Article]
We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing synaptopHluorin (spH), using simultaneous optical and electrophysiological recordings. Synaptic transmission ...
CSP -deficiency causes massive and rapid photoreceptor degeneration [Article]
Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSP_ in mice leads to massive lethal ...
Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells [Article]
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable 02 tension (Po2). In normoxic conditions ...
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease [Article]
In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas. Neurons degenerating in HD develop ...