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Mostrando ítems 1-10 de 28
Artículo
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson’s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal ...
Tesis Doctoral
Células neurosecretoras sensoras de oxígeno y glucosa
(2005-04-20)
El mantenimiento de un medio interno estable, u homesotasia, es especial para los seres vivos. Por ello existen sistemas que controlan cambios en las variables que lo forman para poner en marcha respuestas compensatorias. ...
Artículo
HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing ...
Artículo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
(2016-12)
Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. Here, we report that biotin accumulates in unusually largeamounts in cells of arterial chemoreceptors, ...
Artículo
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
Artículo
Regulation of oxygen sensing by ion channels
(2004)
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O2-sensitive ion channels are major effectors of the cellular responses to ...
Tesis Doctoral
Papel de la cadena de transporte de electrones mitocondrial en la respuesta aguda a hipoxia de los quimiorreceptores arteriales
(2023-10-20)
La respuesta ventilatoria aguda a la hipoxia es un reflejo mediado por las células glómicas quimiosensoras del cuerpo carotídeo (CC). Esta respuesta es vital para contrarrestar los efectos perjudiciales de la hipoxia y ...
Artículo
Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices
(Cell Press, 2021)
Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. However, reliable real-time ROS measurement in cells has been a long-standing methodological ...
Artículo
Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
(National Academy of Sciences, 2022)
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O2-sensing organ is the carotid body (CB), which ...