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Artículo
Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain
(1997)
The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. We have cloned a new K1 channel a-subunit (Kv2.3r) that is unable to form functional channels on ...
Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the ...
Artículo
A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating
(1999)
Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable of forming heterotetramers with other pore-forming subunits to modify their function. We have investigated ...
Tesis Doctoral
Canales iónicos de neuronas septales aisladas: Caracterización electrofisiológica y modulación por TRH y LHRH
(1989-10-02)
El presente trabajo continua con una de las líneas de investigación de nuestro grupo que trata del estudio de las propiedades electrofisiológicas de neuronas del sistema nervioso central de mamíferos. Este estudio se inició ...
Artículo
Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...
Tesis Doctoral
Hipoxia en cardiomiocitos; regulación de la expresión de la subunidad b1 del canal maxi-k y participación en el precondicionamiento cardíaco
(2009-03-09)
The presence of maxi-K channels has been reported in the mitochondria of the cardiac myocytes where it plays a cytoprotective role. Using real-time PCR we have observed that severe chronic hypoxia induces the down-regulation ...
Artículo
Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons
(1991)
Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration of the patch-clamp technique. All cells exhibited a large Na+ current with characteristic fast ...
Artículo
Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)
Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly known. We have studied the post-transcriptional changes in the proteome of mammalian cells elicited ...
Artículo