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Artículo
Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain
(1997)
The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. We have cloned a new K1 channel a-subunit (Kv2.3r) that is unable to form functional channels on ...
Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the ...
Tesis Doctoral
Regulación por dexametasona del canal de ca2 + tipo t cav3.2 en cardiomiocitos. Implicaciones en la hipertrofia cardíaca
(2016-06-01)
Los glucocorticoides son hormonas esteroideas necesarias para la vida que son sintetizadas y liberadas por la glándula adrenal de manera circadiana y en respuesta al estrés (ayuno, hipoglucemia, lesiones físicas, ansiedad ...
Artículo
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels ...
Artículo
A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating
(1999)
Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable of forming heterotetramers with other pore-forming subunits to modify their function. We have investigated ...
Tesis Doctoral
Fisiopatología de la HSA: alteraciones en la funcionalidad vascular en un modelo animal de HSA y cambios en las células mononucleares de sangre periférica de pacientes
(2022-01-17)
Los cambios legislativos que se han producido en la Unión Europea por la aparición de la Directiva UE 2014-24 sobre contratación pública, han transformado el paradigma en el control de costes de la edificación pública. ...
Artículo
Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant
(Wiley Periodicals, LLC., 2021-07)
SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an overlapping phenotype. Functional consequences of SCN5A variants assessed by patch‐clamp electrophysiology ...
Tesis Doctoral
Canales iónicos de neuronas septales aisladas: Caracterización electrofisiológica y modulación por TRH y LHRH
(1989-10-02)
El presente trabajo continua con una de las líneas de investigación de nuestro grupo que trata del estudio de las propiedades electrofisiológicas de neuronas del sistema nervioso central de mamíferos. Este estudio se inició ...
Artículo
Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia
(BMJ Publishing Group, 2020)
Background: Since 1994, over 50 families affected by the episodic ataxia type 1 disease spectrum have been described with mutations in KCNA1, encoding the voltage-gated K+ channel subunit Kv1.1. All of these mutations are ...