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Tesis Doctoral
Artículo
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Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells inAMslices of neonatal and adult ...
Tesis Doctoral
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Caracterización de los canales de potasio dependientes de voltaje (Kv) de los adipocitos blancos de rata
(2022-07-21)
Los adipocitos blancos son células que participan en el metabolismo energético, mediante el almacenamiento de energía y la secreción, entre otras moléculas, de adipoquinas, que participan en la regulación metabólica. Su ...
Artículo
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Peripheral Organ Equivalent Dose Estimation Procedure in Proton Therapy
(Frontiers Research Foundation, 2022)
The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in ...
Artículo
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Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
(Nature Publishing Group, 2021-06-12)
SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting ...
Artículo
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R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
(Elsevier, 2020-02-21)
Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application ...
Artículo
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Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related ...
Artículo
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Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals
(SOC NEUROSCIENCE, 2009)
The spatial relationship of exocytosis and endocytosis in motor nerve terminals has been explored, with varied results, mostly in fixed preparations and without direct information on the utilization of each exocytic site. ...
Artículo
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...