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IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner
(Willey, 2022)
Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates phagocytosis of reactive astrocytes through p110α isoform of phosphatidylinositol 3-kinase ...
Artículo
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals LLC, 2017-09-08)
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 ...
Artículo
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Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells
(Science Direct, 2001-08-27)
Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, allowing rapid retrieval from the plasma membrane of fused vesicles for future use. This can be a much ...
Tesis Doctoral
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Regulation of miRNA expression during Sorafenib treatment in hepatocellular carcinoma. Development of a new therapeutic approach
(2023-04-17)
Hepatocellular carcinoma (HCC) is one of the most frequent neoplasias and one of the major causes of cancer-related death worldwide. It usually arises upon chronic liver damage in cirrhotic livers. Several etiologies with ...
Artículo
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, ...
Tesis Doctoral
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Caracterización del papel de la hipoxia en senescencia y cómo su alteración contribuye a la inmortalización celular y la tumorigénesis
(2020-12-16)
La senescencia celular es un estado fisiológico complejo de las células caracterizado por la parada proliferativa, los cambios en la estructura de la cromatina, modificaciones epigenéticas específicas, cambios metabólicos, ...
Tesis Doctoral
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Estudio de los mecanismos fisiopatológicos de la ruta sináptica de Neurexinas y Neuroliguinas en la enfermedad de Alzheimer
(2023-06-29)
La enfermedad de Alzheimer (AD) es una enfermedad neurodegenerativa asociada con el envejecimiento caracterizada por un deterioro progresivo de la memoria. La pérdida de la función sináptica es un factor temprano que ...