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Artículo
Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ...
Artículo
LPS priming before plaque deposition impedes microglial activation and restrains Abeta pathology in the 5xFAD mouse model of Alzheimer's disease.
(Elsevier, 2023-10)
Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer’s disease (AD). AD is characterized by chronic neuroinflammation, ...
Artículo
The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)
Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α -synuclein and progressive degeneration of ...
Artículo
The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches
(Wiley-Blackwell, 2021)
Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors that populate the developing CNS. Interestingly, a specific type of bone marrow-derived monocyte ...
Artículo
Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth
(Elsevier, 2024-04-16)
Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although the involvement of Gal-3 in tumour progression, ...