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Artículo
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021-01-10)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal of extra cells during early developmental stages. Hence, an impairment of this process may thus ...
Artículo
HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
(Frontiers Media, 2020)
Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death ...
Artículo
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
(Frontiers Media S.A., 2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing ...
Artículo
The HERC proteins and the nervous system
(Elsevier, 2021)
The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which encode Large HERC proteins -HERC1 and HERC2- with ...
Artículo
The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their ...