Now showing items 1-4 of 4
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model [Article]
(Impact Journals, LLC, 2015)
Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and ...
Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol [Article]
(MDPI AG, 2016)
A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural olive oil phenol, in order to increase the assortment of compounds with potential neuroprotective ...
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density [Article]
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that ...
How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins [Article]
Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and stability, and for improving our ability to design highly stable enzymes with potential biotechnological ...