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AuthorVitorica Ferrández, Francisco Javier (8)Sánchez Varo, Raquel María (6)Gómez Arboledas, Ángela (5)Sánchez Mejías, Elisabeth (5)Vizuete Chacón, María Luisa (5)Fernández Valenzuela, Juan José (4)Jiménez Muñoz, Sebastián (4)Navarro Garrido, Victoria (4)Sánchez Mico, María (4)Venero Recio, José Luis (4)... View MoreSubjectAlzheimer’s disease (3)Microglia (2)3D cultures (1)AbAEE (1)ACUTE TOXICITY (1)AGARICUS BISPOROUS (1)Alzheimer (1)Alzheimer’s disease (AD) (1)Amyloid (1)Amyloid aggregation (1)... View MoreDate Issued2018 (4)2020 (4)2019 (2)2017 (1)2021 (1)2022 (1)Funding agency
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) (13)
Junta de Andalucía (8)Instituto de Salud Carlos III (7)Ministerio de Economía y Competitividad (MINECO). España (5)Universidad de Málaga (4)Universidad de Sevilla (2)Centro de Invesitgacion Biomedica en Red Enfermedades Neurodegenetativas. (CIBERNED) España (1)Centro de Investigaciones Biomédicas en Red (CIBERNED) (1)Centro de Investigaciones Biomédicas en Red (CIBERNED). España (1)Centro de Investigación Biomédica en Red (CIBERNED) (1)... View More
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Article
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RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation 

Buchrieser, Julian; Oliva Martín, María José; Moore, Michael D.; Long, Joshua C. D.; Cowley, Sally A.; Long, Joshua C. D.; Pérez Simón, José Antonio; Venero Recio, José Luis (Springer Nature, 2018)
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory ...
Article
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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease 

García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the ...
Article
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Preliminary Studies of the Toxicity of Agaricus Bisporous Aqueous Enzymatic Extracts (AbAEE) In Rats 

Carbonero Aguilar, María del Pilar; Falcón García, Gonzalo; Gallego Yerga, Paloma; Campo, J.A. del; Moreno Navarro, Isabel María; Bautista Palomas, Juan Dionisio (Avens Publishing Group, 2018)
The health benefits of extracts from Agaricus bisporus greatly extend its use as components of new functional foods for the treatment and prevention of diseases, rather than restricting it to a good food with high nutritional ...
Article
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HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory 

Pérez Villegas, Eva María; Pérez Rodríguez, Mikel; Negrete Díaz, José V.; Ruiz Laza, Rocío; Rosa, José Luis; Álvarez de Toledo, Guillermo; Rodríguez Moreno, Antonio; Armengol, José Ángel (Frontiers Media, 2020)
Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death ...
Article
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Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still notfully understood, since different ...
Article
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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model 

Fernández Valenzuela, Juan José; Muñoz Castro, Clara; Jiménez Muñoz, Sebastián; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutierrez Pérez, Antonia (Nature Research, 2020)
In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ...
Article
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Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients 

Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; García León, Juan Antonio; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ...
Article
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Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease 

Sánchez Mico, María; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Romero Molina, Carmen; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier (Wiley, 2020)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ...
Article
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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors 

Hajji, Nabil; García Revilla, Juan; Sarmiento Soto, Manuel; Perryman, Richard; Symington, Jake J.; Quarles, Chad C.; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; Venero Recio, José Luis; Syed, Nelofer (American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Article
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Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease 

Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ...
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