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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
(Nature Research, 2020)
In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ...
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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
(Elsevier, 2011-01)
We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. ...
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
(BMC, 2020)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...
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Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation ...
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The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)
Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α -synuclein and progressive degeneration of ...
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1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013)
1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death L Manterola 1,12 , M Hernando-Rodr ı ́ guez 2,12 , A Ruiz 3,4 , A Apraiz 5 , O Arrizabalaga 5 , L Vello ́ n 6 , E ...
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Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)
Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s disease. On this review we firstly, describe some human epidemiological studies that highlight the ...
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Lactic acid bacteria from fermented whey as a biocontrol tool against phytopathogenic microorganisms
(OMICS International, 2015)
Biological control is a bioeffector-method that uses organisms to control populations of other organisms. This method is widely used to prevent pests, diseases and weeds proving to be a viable alternative to avoid using ...
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Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry
(Elsevier, 2015-01-05)
The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery of potential markers for diagnosis and disease monitoring. In this study, we investigated regional ...