ListarArtículos (Bioquímica y Biología Molecular) por materia "Alzheimer’s disease"
Mostrando ítems 1-16 de 16
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
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Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
(BMC, 2022)Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
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Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death
(IOS Press, 2016-06-07)Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
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Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
(BMC, 2022)Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s ...
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
(2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
(BMC, 2022)Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life ...
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Editorial: Sex differences in aging: a cognitive and behavioral perspective
(Frontiers Media, 2024-01-22) -
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Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
(Frontiers Media, 2018)Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, ...
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Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease
(MDPI, 2020)Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
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Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus
(Springer Nature, 2023)Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
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Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
(Wiley, 2018)Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
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Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
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Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
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Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...
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Update on modifiable risk factors for Alzheimer’s disease and related dementias
(Wolters Kluwer, 2024)Purpose of review. All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such ...
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Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
(Future Science Group, 2019)Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together ...