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Mostrando ítems 1-10 de 11
Artículo
Role of leptin in non-alcoholic fatty liver disease
(MDPI, 2021-06-30)
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this ...
Artículo
Possible Role of Leptin in Atopic Dermatitis: A Literature Review
(MDPI, 2021-11-05)
Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases ...
Artículo
Leptin, both bad and good actor in cancer
(MDPI, 2021)
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage ...
Artículo
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
(MDPI AG, 2022)
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases ...
Artículo
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, ...
Artículo
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels seem to have a role modulating the growth of these tumours. Sam68 is an RNA-binding protein with ...
Artículo
Leptin and Nutrition in Gestational Diabetes
(MPDI, 2020-07-02)
Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an important autocrine trophic effect. Moreover, increased leptin levels are found in the most frequent pathology of pregnancy: ...
Artículo
Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis
(MDPI, 2022-12-29)
Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma. Adipose tissue secretes ...
Artículo
Obesity-associated metabolic disturbances reverse the antioxidant and anti-inflammatory properties of high-density lipoproteins in microglial cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
High-density lipoproteins (HDLs) play an important role in reverse cholesterol transport and present antioxidant properties, among others. In the central nervous system (CNS), there are HDLs, where these lipoproteins could ...
Artículo
Role of leptin in inflammation and vice versa
(2020-08-16)
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other ...