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Listar Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja) por autor "Sánchez Fernández, Elena Matilde"
Mostrando ítems 1-9 de 9
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Artículo
Antileishmanial activity of sp2-iminosugar derivatives
Sánchez Fernández, Elena Matilde; Gómez Pérez, Veronica; García Hernández, Raquel; García Fernández, José Manuel; Plata, Gabriela B.; Padrón, José M.; Ortiz Mellet, Carmen; Catanys, Santiago; Gamarro, Francisco (Royal Society of Chemistry, 2015)A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ...
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Artículo
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
Navo, C.D.; Corzana, F.; Sánchez Fernández, Elena Matilde; Busto, J.H.; Avenoza, A.; Namba, E.; Higaki, Katsumi; Ortiz Mellet, Carmen; García Fernández, José Manuel; Peregrina, J.M. (Royal Society of Chemistry, 2016)A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ...
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Artículo
Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017)Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
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Artículo
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Artículo
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
Schaeffer, Evelyne; Sánchez Fernández, Elena Matilde; Gonçalves-Pereira, Rita; Flacher, Vincent; Lamon, Delphine; Duval, Monique; Fauny, Jean Daniel; García Fernández, José Manuel; Mueller, Christopher G.; Ortiz Mellet, Carmen (Elsevier, 2019)Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ...
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Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
Rocha, Gabriel; Ramírez Cárdenas, Jonathan; Padilla Pérez, María del Carmen; Walpole, Samuel; Nepravishta, Ridvan; García Moreno, M. Isabel; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; Angulo, Jesús; Muñoz García, Juan Carlos (American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
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Artículo
Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis
Herrera González, Irene; Sánchez Fernández, Elena Matilde; Sau, Abhijit; Nativi, Cristina; Garciá Fernández, José M.; Galán, M. Carmen; Ortiz Mellet, Carmen (American Chemical Society, 2020)The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ...
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Artículo
Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
Gómez Jaramillo, Laura; Cano Cano, Fátima; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; García Fernández, José Manuel; Alcalá, Martín; Álvarez Gallego, Fabiola; Iturregui, Marta; González Montelongo, M. Carmen; Campos Caro, Antonio; Arroba, Ana I.; Aguilar Diosdado, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the ...