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Article
Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives
(American Chemical Society, 2023)
β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling capabilities. The aromatic modules can participate in inclusion phenomena and/or aromatic-aromatic ...
Article
P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules
(MDPI, 2019)
A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus ...
PhD Thesis
Carbohydrate multivalent systems to functionalize proteins and surfaces for lectin interaction studies
(2019-04-11)
Las interacciones entre proteínas y carbohidratos están involucradas en muchos eventos biológicos fundamentales. En estos procesos, una clase de proteínas que reconocen azúcares denominadas lectinas juegan un papel ...
Article
Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis
(Wiley-Blackwell, 2021)
A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones as neutral α-azo carbanions and masked acyl anion equivalents has been developed. Experimental ...
Article
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural ...
Article
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019-10-01)
Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin skeleton and an organoselenium motif. Three families were obtained: isoselenocyanate, selenocarbamates ...
PhD Thesis
PhD Thesis
Funcionalización asimétrica de compuestos carbonílicos mediante organocatálisis bifuncional
(2015-03-20)
OBJETIVOS La mayor parte de las investigaciones realizadas recientemente en el campo de la organocatálisis asimétrica se centran en el diseño de nuevos catalizadores de actividad mejorada y el desarrollo de nuevos procesos ...
Patent. Invention
Utilización de derivados bicíclicos de 1-desoxigalactonojirimicina en la preparación de un medicamento para el tratamiento de enfermedades relacionadas con beta-enzimas galactosidasas lisosómicas mutantes humanas
(Oficina Española de Patentes y Marcas (OEPM), 2015-04-23)
La presente invención se refiere a un uso de un compuesto de fórmula (I) o una de sus sales, donde R representa una cadena alifática, lineal o ramificada, que se selecciona del grupo que consiste en cadena hidrocarbonada ...
Article
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
(Royal Society of Chemistry: Open Access, 2019)
The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the first clinical agent has now been approved, but PPIs remain difficult targets for the development of ...