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Mostrando ítems 201-210 de 466
Artículo
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Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation
(Wiley, 2016)
The dynamic kinetic Pd0 -catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/ (S)-QUINAP as the ...
Artículo
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Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach ...
Tesis Doctoral
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Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato
(2007-03-23)
Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia de mimeticos oligosacarídicos que incorporan puentes intersacarídicos de tipo pseudoamida: urea, ...
Artículo
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The Role of Two Linear β-Glucans Activated by c-di-GMP in Rhizobium etli CFN42
(MDPI, 2022)
Bacterial exopolysaccharides (EPS) are secreted biopolymers with often critical roles in bacterial physiology and ecology. In addition to their biological role, there is increasing interest for EPS in various industrial ...
Tesis Doctoral
Artículo
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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ...
Artículo
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
(Royal Society of Chemistry, 2022)
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material ...
Artículo
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Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance
(Elsevier, 2021)
Drug resistance remains the major cause of cancer treatment failure especially at the late stage of the disease. However, based on their versatile chemistry, metal and metalloid compounds offer the possibility to design ...
Tesis Doctoral
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Gliconanopartículas de oro: un nuevo sistema multivalente para el estudio de las interacciones biológicas de los carbohidratos
(2002-12)
La mayoría de los glicoconjugados de la superficie celular actúan como receptores específicos de virus, toxinas y de otras células. A menudo las interacciones que se establecen entre receptor-ligando son de baja de afinidad, ...
Artículo
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AuI-Catalyzed Haloalkynylation of Alkenes
(Wiley-Blackwell, 2020)
The formal insertion of alkenes into aromatic chloro- and bromoalkynes takes place under cationic gold catalysis. This haloalkynylation reaction can be performed with cyclic, gem-disubstituted and monosubstituted alkenes, ...