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Listar Química Orgánica por autor "Ortiz Mellet, Carmen"
Mostrando ítems 21-40 de 85
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Artículo
Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions
Neva, Tania; Carmona, Thais; Benito, Juan M.; Przybylski, Cédric; Ortiz Mellet, Carmen; Mendicuti, Francisco; García Fernández, José Manuel (Frontiers Media, 2019)The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ...
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Artículo
Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
Peinado, M.J.; Echávarri, A; Ruiz, R.; Suárez Pereira, E.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Rubio, L. A. (Elsevier, 2013)In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ...
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Artículo
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
Fuente, Alex de la; Rísquez Cuadro, Rocio; Verdaguer, Xavier; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen; Riera, Antoni (Elsevier, 2016)Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
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Artículo
Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan Manuel; Jiménez Blanco, José Luis; Santana Armas, María Luisa; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2022)A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
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Tesis Doctoral
Estrategias de glicosidación con sp2-iminoazúcares. Síntesis de miméticos de manooligosacáridos multivalentes y estudio de sus interacciones con lectinas de tipo-C mediante técnicas espectroscópicas, computacionales y biofísicas
Herrera González, Irene (2022-12-02)Los iminoazúcares, análogos de carbohidratos en los que se ha sustituido el oxígeno endocíclico por un átomo de nitrógeno, ...
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Artículo
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Tesis Doctoral
Glicobióticos: desarrollo de caramelos con propiedades funcionales
Atencio Genes, Loyda Esther (2017-07-17)La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ...
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Tesis Doctoral
Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos
Rodríguez Lavado, Julio (2015-11-27)En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ...
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Tesis Doctoral
Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato
Bootello Iglesias, Purificación (2007-03-23)Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ...
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Tesis Doctoral
Glicoterapias contra el cáncer, la leishmania y enfermedades de depósito lisosomal
Gonçalves Pereira, Rita Alexandra (2016-05-06) -
Artículo
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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Artículo
High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin
Herrera González, Irene; González Cuesta, Manuel; Thépaut, Michel; Laigre, Eugénie; Goyard, David; Rojo, Javier; García Fernández, José Manuel; Ortiz Mellet, Carmen (Wiley, 2023-10-12)The “carbohydrate chemical mimicry” exhibited by sp2-iminosugars has been utilized to develop practical syntheses for ...
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Artículo
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
Khanal, Manakamana; Larsonneur, Fanny; Raks, Victoriia; Barras, Alexandre; Baumann, Jean-Sébastien; Martin, Fernando Ariel; Martin, Fernando Ariel; Boukherroub, Rabah; Ghigo, Jean Marc; Ortiz Mellet, Carmen; Zaitsev, Vladimir; Garcia Fernandez, Jose M.; Beloin, Christophe; Siriwardena, Aloysius; Szunerits, Sabine (Royal Society of Chemistry, 2015)Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ...
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Artículo
Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
Díaz Moscoso, Alejandro; Vercauteren, Dries; Rejman, Joanna; Benito, Juan M.; Ortiz Mellet, Carmen; De Smedt, Stefaan C.; Fernández, José M. García (Elsevier, 2010)It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ...
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Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
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Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
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Artículo
Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips
Neva, Tania; Ortiz Mellet, Carmen; Fernández, José M. García; Benito, Juan M. (Taylor & Francis, 2019)The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ...
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Artículo
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019)Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
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Artículo
New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells
Allan, Ghada; Ouadid-Ahidouch, Halima; Sánchez Fernández, Elena Matilde; Risquez Cuadrado, Rocío; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ahidouch, Ahmed (Public Library of Science, 2013)sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ...
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Artículo
Novel Therapies for Orphan Diseases
García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ...