Browsing Química Orgánica by Issue Date
Now showing items 181-200 of 460
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PhD Thesis
Insights on the structure and dynamics of glycosaminoglycans and their interactions with langering: NMR and computational studies
(2013-10-25)La determinación de las estructuras tridimensionales de los oligosacáridos así como la comprensión de las bases moleculares ...
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PhD Thesis
Strategies towards selective functionalization of polycationic amphiphilic cyclodextrins (paCDs): engineering novel non-viral gene carriers by tailoring self-assembling and DNA-condensing capabilities
(2013-11-22)The use of preorganized macrocyclic scaffolds to achieve a precise alignment of functional elements has proven to be ...
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PhD Thesis
Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1
(2013-12-13)Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ...
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Article
Structure and biological roles of Sinorhizobium fredii HH103 exopolysaccharide
(Public Library of Science, 2014)Here we report that the structure of the Sinorhizobium fredii HH103 exopolysaccharide (EPS) is composed of glucose, ...
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Article
Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
(Arkat USA, 2014)A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...
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Article
Structural basis of pharmacological chaperoning for human β-galactosidase
(Elsevier, 2014)GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ...
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Article
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014)Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
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PhD Thesis
Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas
(2014-02-26)En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ...
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Patent. Invention
Uso de un compuesto de fórmula (i) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de gaucher, composición farmacéutica, un compuesto de fórmula (ib) y procedimiento de obtención.
(Oficina Española de Patentes y Marcas (OEPM), 2014-10-01)Uso de un compuesto de fórmula (I) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de ...
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PhD Thesis
Síntesis de oligosacáridos de ácido hialurónico y sulfato de condroitina y evaluación de sus interacciones con proteínas por polarización de fluorescencia
(2014-10-03)Los Glicosaminoglicanos o GAGs, una de las clases más importantes de moléculas extracelulares, son cadenas polisacarídicas ...
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PhD Thesis
Preparación de nanosistemas por autoensamblaje de ciclodextrinas y calixarenos. Aplicaciones al transporte y a la liberación controlada de genes y fármacos
(2014-11-07)En esta Tesis hemos diseñado entidades moleculares basadas en derivados de beta-ciclodextrina y calix[4]areno capaces de ...
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Article
Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti
(National Academy of Sciences, 2015)An artificial increase of cyclic diguanylate (c-di-GMP) levels in Sinorhizobium meliloti 8530, a bacterium that does not ...
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PhD Thesis
Síntesis y Estudio de Sistemas Orgánicos con uno o más Espines Electrónicos Desapareados, Altamente Estables y Persistentes, Basados en el Radical BDPA
(2015)Desde que comenzó su desarrollo a principios del siglo XX, la Química Orgánica de Radicales ha dado lugar a numerosos y ...
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Article
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported ...
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Article
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015)Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ...
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Article
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
(Nature Publishing Group, 2015)Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ...
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Article
Strongly Emissive and Photostable Four-Coordinate Organoboron N,C Chelates and Their Use in Fluorescence Microscopy
(Wiley-Blackwell, 2015)Six strongly fluorescent four-coordinate organoboron N,C chelates containing an aryl isoquinoline skeleton were prepared. ...
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Article
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
(Royal Society of Chemistry, 2015)Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ...
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Article
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015)2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...
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Article
Synthesis of hyperpolarizable biomaterials at molecular level based on pyridinium-chitosan complexes
(Universidade Federal do Espírito Santo, 2015)Potential NLO-phore materials based on chitosan are described for the first time in this study. A series of fluorescent ...